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In addition, although the NS deletion mutants grew to wild-type rBRSV levels in cells lacking a functional IFN-a/b system, their replication as severely inhibited in IFNcompetent cells98 These results suggested that the NS proteins block induction of IFN-a/b gene expression Wild-type human respiratory syncytial virus (HRSV) is a poor inducer of a/b interferons (IFN-a/b) In accord with the results seen with BRSV, recombinant HRSV lacking the NS1 and NS2 genes was able to induce high levels of IFN-a and IFN-b in epithelial cells and macrophages99 The two proteins can function independently or coordinately Alphaviruses including Venezuelan (VEEV), eastern (EEEV), and western equine encephalitis viruses (WEEV) are potential agents of biological warfare and terrorism and important, naturally emerging zoonotic viruses A representative virus of this group is Sindbis virus, which possesses a nonstructural protein nsP2 that is a signi cant regulator of Sindbis virus host cell interactions.

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Free online Word to PDF converter without email. Free C# .NET library and components for .NET framework. Description: Convert to PDF/TIFF and save it on the ...

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Vector and Bitmap Graphics Just as display devices have two general methods of operation, graphics file formats can be divided into two general classes, vector and bitmap2 Vector graphics formats use a series of drawing commands to represent an image A Windows metafile is a commonly used vector graphics format Figure 13 contains a simple vector image created using commands to draw two arcs nd a rectangle Vector graphics formats are not limited to output devices, such as plotters, that create images through drawing commands Computer monitors and laser printers usually have software that converts vector commands into pixels There are two main drawbacks with vector graphics First, they are not suitable for reproducing photographs or paintings A painting such as Whistlers Mother would require tens of thousands of drawing commands simply determining which commands to use to represent the painting would be a monumental task Second, complex images take a long time to display On most display systems, each vector object has to be converted to a pixel image All of the image formats covered in this book are bitmap image formats Such formats represent images as 2-dimensional arrays where each array element represents a color to be displayed at a specific location When displayed on a computer screen, each element is generally mapped to a single screen pixel If pixels are close enough on the display device, it becomes difficult for the human eye to detect the array structure that composes the image The greatest advantage of bitmap images is their quality As the amount of disk space and memory has increased along with the speed of processors, the use of bitmap images has expanded as well One of the most visible examples of this is in the computer game industry Currently even games that require high performance, such as flight simulators and shoot-em-ups, use bitmap graphics Contrast the graphics in games like Quake and Doom to the vector graphics of Tank or even the Death Star graphics in the original Star Wars movie A major drawback with bitmap images is the amount of data required to hold them The size of an image in bytes (not counting overhead) is width height bits per pixel + 7 8 Thus, an 800 x 600 image with 24 bits per pixel requires 1,440,000 bytes of memory to display or disk space to store As the amount of memory on computers has grown, so has the number and size of images that can be displayed at the.

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This protein not only is a component of the replicative enzyme complex required for replication and transcription of viral RNAs but also plays a role in suppressing the antiviral response in Sindbis virus-infected cells nsP2 may act by decreasing interferon (IFN) production100,101 In another study, White and co-workers102 found that a single change (G to A) at nucleotide 3 of the 50 untranslated region (UTR) of the Venezuelan equine encephalitis virus (VEEV) V3000 virulent strain genome resulted in a virus that was avirulent in mice This mutant showed no growth disadvantage compared to the wild-type virus in cells derived from IFN-a/bR( / )mice Induction of IFN-a/b was the same for avirulent and virulent viruses; however, the avirulent mutant virus was more sensitive than the virulent strain to the antiviral actions of IFN-a/b Thus, increased sensitivity to IFN-a/b must play a major role in the in vivo attenuation.

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Virus zoonoses causing hemorrhagic fevers include the Bunyaviridae Thomas et al103 found that bunyaviruses activate PKR but are only marginally sensitive to its antiviral effect In addition, NSs appeared to be different from other IFN antagonists, since it inhibited dsRNA-dependent IFN induction but had no effect on the dsRNA-activated PKR and RNase L systems Bunyamwera virus, of the family Bunyaviridae, possesses a nonstructural protein NSs that is a virulence factor that inhibits IFN-b gene expression in the mammalian host In an unconventional mechanism of interferon antagonism, NSs targets the RNA polymerase II (RNAP II) complex103 106 Rift Valley fever virus (RVFV), a phlebovirus of the family Bunyaviridae, is a major public health threat in Egypt and sub-Saharan Africa Bouloy and coworkers107 could show that the ability of RVFV to inhibit IFN-a/b production correlated with viral virulence, thereby suggesting that the accessory protein NSs is an interferon antagonist.

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